6svk: Difference between revisions
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==human Myeloid-derived growth factor (MYDGF)== | |||
<StructureSection load='6svk' size='340' side='right'caption='[[6svk]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6svk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SVK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SVK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6svk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6svk OCA], [http://pdbe.org/6svk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6svk RCSB], [http://www.ebi.ac.uk/pdbsum/6svk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6svk ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MYDGF_HUMAN MYDGF_HUMAN]] Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).[UniProtKB:Q9CPT4]<ref>PMID:25581518</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Ebenhoch, R]] | |||
[[Category: Nar, H]] | |||
[[Category: Cytokine]] | |||
[[Category: Growth factor]] | |||
[[Category: Ischemic tissue repair]] | |||
[[Category: Mydgf]] | |||
[[Category: Orphan ligand]] | |||
[[Category: Reduces scar size after myocardial infarction]] | |||
[[Category: Unique cytokine fold]] | |||
Revision as of 06:58, 27 November 2019
human Myeloid-derived growth factor (MYDGF)
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