Neurotransmitters: Difference between revisions
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*<scene name='46/464134/Cv/3'>Glutamate is bound to Metabotropic Glutamate Receptor, GluR1</scene>. | *<scene name='46/464134/Cv/3'>Glutamate is bound to Metabotropic Glutamate Receptor, GluR1</scene>. | ||
===Ionotropic Glutamate Receptors=== | ===Ionotropic Glutamate Receptors=== | ||
Ionotropic Glutamate Receptors '''(IGluRs)''' are a family of ligand-gated ion channels that are responsible for fast excitatory neurotransmission.<ref name="Jin">PMID: 16192394</ref> Primarily localized to nerve synapses in mammals, IGluRs are implicated in nearly all aspects of nervous system development and function.<ref name="Sobo">PMID: 19946266</ref> Synapses form the connection between two neuronal cells. Within synapses, neurotransmitters are released from vesicles in presynaptic cells and interact with receptors in postsynaptic cells to allow for communication between nerve cells.<ref name="Jin"/> GluR domains include the amino terminal domain (ATD), transmembrane domain (TMD) and ligand-binding domain (LBD). Glutamate is the predominant neurotransmitter of excitatory synapses and interacts specifically with AMPA and NMDA IGluRs.<ref name="Purcel"/> | |||
*'''AMPA receptor''' is a non-NMDA-type IGluR<br /> | |||
*'''Kainate receptor''' (GluK) is a non-NMDA-type IGluR which is activated by the agonist kainate.<br /> | |||
*'''NMDA receptor''' (NMDAR) is a IGluR which binds to the agonist NMDA. It contains subuntis NR1, NR2A, NR2B, NR2C, NR2D, NR3A, NR3B.<br /> | |||
*[[Ionotropic Glutamate Receptors]] | *[[Ionotropic Glutamate Receptors]] | ||
*[[Glutamate receptor (GluA2)]] | *[[Glutamate receptor (GluA2)]] | ||
