Sandbox Reserved 1578: Difference between revisions
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<scene name='82/824623/Helix_interactions/1'>Text To Be Displayed</scene>{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <scene name='82/824623/Helix_interactions/1'>Text To Be Displayed</scene>{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==SAM | ==SAM Riboswitch== | ||
<Structure load='2gis' size='350' frame='true' align='right' caption='SAM Riboswitch' scene='SAM Riboswitch' /> | <Structure load='2gis' size='350' frame='true' align='right' caption='SAM Riboswitch' scene='SAM Riboswitch' /> | ||
S-adenosylmethionine (SMA) is a riboswitch, which are structured noncoding RNA domains that selectively bind metabolites and control gene expression. Nearly all examples of the known riboswitches reside in noncoding regions of messenger RNAs where they control transcription or translation.<ref name=“ref1">PMID:16810258</ref> | S-adenosylmethionine (SMA) is a riboswitch, which are structured noncoding RNA domains that selectively bind metabolites and control gene expression. Nearly all examples of the known riboswitches reside in noncoding regions of messenger RNAs where they control transcription or translation.<ref name=“ref1">PMID:16810258</ref> | ||
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The SAM ligand is bound within a pocket created by the <scene name='82/824623/Helix_interaction/2'>Helix Interaction</scene> (purple). The SAM ligand adopts a compact conformation in which the methionine stacks upon the adenine ring, stabilized in part by the π-cation interaction with the amino group pointing toward the adenine ring. Also the compact configuration of SAM creates a hydrogen bonding interaction to helix P3 and van der Waals forces interacting with the minor groove of the P1 helix.<ref name="ref1" /> | The SAM ligand is bound within a pocket created by the <scene name='82/824623/Helix_interaction/2'>Helix Interaction</scene> (purple). The SAM ligand adopts a compact conformation in which the methionine stacks upon the adenine ring, stabilized in part by the π-cation interaction with the amino group pointing toward the adenine ring. Also the compact configuration of SAM creates a hydrogen bonding interaction to helix P3 and van der Waals forces interacting with the minor groove of the P1 helix.<ref name="ref1" /> | ||
The adenine ring of SAM is the central position between five nucleotides. The nucleotides interact by hydrogen bond attractions between themselves and the SAM ligand to stabilize position <scene name='82/824623/Nitrogenous_base_interactions/3'>Nucleotide Interaction</scene>(orange). <ref name="ref1" /> | The adenine ring of SAM is the central position between five nucleotides. The nucleotides interact by hydrogen bond attractions between themselves and the SAM ligand to stabilize position <scene name='82/824623/Nitrogenous_base_interactions/3'>Nucleotide Interaction</scene>(orange). <ref name="ref1" /> | ||
