Sandbox Reserved 1578: Difference between revisions
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<scene name='82/824623/Helix_interactions/1'>Text To Be Displayed</scene>{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <scene name='82/824623/Helix_interactions/1'>Text To Be Displayed</scene>{{Sandbox_Reserved_JMeans}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==SAM Riboswitch== | ==SAM Riboswitch== | ||
==Overview== | |||
<Structure load='2gis' size='350' frame='true' align='right' caption='SAM Riboswitch' scene='SAM Riboswitch' /> | <Structure load='2gis' size='350' frame='true' align='right' caption='SAM Riboswitch' scene='SAM Riboswitch' /> | ||
S-adenosylmethionine (SAM) is a riboswitch, which are structured noncoding RNA domains that selectively bind metabolites and control gene expression. Nearly all examples of the known riboswitches reside in noncoding regions of messenger RNAs where they control transcription or translation.<ref name="ref1">PMID:16810258</ref> | S-adenosylmethionine (SAM) is a riboswitch, which are structured noncoding RNA domains that selectively bind metabolites and control gene expression. Nearly all examples of the known riboswitches reside in noncoding regions of messenger RNAs where they control transcription or translation.<ref name="ref1">PMID:16810258</ref> | ||
== Structural | == Structural Highlights == | ||
The key architecture of SAM riboswitch is composed of ligand-induced interactions between one helix and the 3' side of another helix surrounding the SAM ligand as well as hydrogen bonding interactions between the adenosine base of SAM and interactions between the main chain atoms of methionine with nucleotide interactions. <ref name="ref1" /> | The key architecture of SAM riboswitch is composed of ligand-induced interactions between one helix and the 3' side of another helix surrounding the SAM ligand as well as hydrogen bonding interactions between the adenosine base of SAM and interactions between the main chain atoms of methionine with nucleotide interactions. <ref name="ref1" /> | ||
