Protein phosphatase: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='54/540142/Cv/1' caption='Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate [[3k7v]]'> | <StructureSection load='' size='350' side='right' scene='54/540142/Cv/1' caption='Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate [[3k7v]]'> | ||
__TOC__ | |||
== Function == | == Function == | ||
'''Protein phosphatases''' (PP) or '''serine/threonine protein phosphatase''' regulate protein phosphorylation and thus are key in intracellular signal transduction processes.<br /> | '''Protein phosphatases''' (PP) or '''serine/threonine protein phosphatase''' regulate protein phosphorylation and thus are key in intracellular signal transduction processes.<br /> | ||
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*<scene name='54/540142/Cv/6'>Mn+2 ion cofactors coordination site</scene>. | *<scene name='54/540142/Cv/6'>Mn+2 ion cofactors coordination site</scene>. | ||
*<scene name='54/540142/Cv/7'>Whole binding site</scene>. | *<scene name='54/540142/Cv/7'>Whole binding site</scene>. | ||
== 3D Structures of protein phosphatase== | |||
[[Protein phosphatase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of protein phosphatase== | == 3D Structures of protein phosphatase== | ||
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**[[3n5u]] – hPP1A catalytic subunit + retinoblastoma-associated protein<br /> | **[[3n5u]] – hPP1A catalytic subunit + retinoblastoma-associated protein<br /> | ||
**[[4g9j]], [[5ioh]] – hPP1A catalytic subunit + peptide<br /> | **[[4g9j]], [[5ioh]] – hPP1A catalytic subunit + peptide<br /> | ||
**[[6b67]] – hPP1A catalytic subunit (mutant) + peptide<br /> | |||
*Protein phosphatase 1G | *Protein phosphatase 1G | ||
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**[[4da1]] - hPP1K + Mn<br /> | **[[4da1]] - hPP1K + Mn<br /> | ||
**[[6ak7]] – hPP1K (mutant) + Mg<br /> | |||
*Protein phosphatase 2A | *Protein phosphatase 2A or serine/threonine-protein phosphatase 2A | ||
**[[1b3u]], [[2g62]], [[2hv6]] – hPP2A regulatory subunit <br /> | **[[1b3u]], [[2g62]], [[2hv6]], [[4mew]], [[4i5k]], [[4i5j]], [[2jak]], [[2ixm]], [[2hv7] – hPP2A regulatory subunit <br /> | ||
**[[5swf]], [[5k6s]], [[5jja]] – hPP2A regulatory subunit + BUBR1<br /> | |||
**[[5sw9]] – hPP2A regulatory subunit + REPOMAN<br /> | |||
**[[2pkg]], [[2pf4]] – hPP2A regulatory subunit + small T antigen<br /> | |||
**[[2ie3]], [[2ie4]], [[2npp]], [[2nyl]], [[2nym]] – hPP2A catalytic + regulatory subunit + tumor-inducing toxin<br /> | **[[2ie3]], [[2ie4]], [[2npp]], [[2nyl]], [[2nym]] – hPP2A catalytic + regulatory subunit + tumor-inducing toxin<br /> | ||
**[[3c5w]] – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase<br /> | **[[3c5w]] – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase<br /> | ||
**[[3p71]], [[2iae]] – hPP2A catalytic + regulatory subunit + LCMT-1 <br /> | |||
**[[3dw8]] – hPP2A catalytic + regulatory subunit (mutant) + LCMT-1 <br /> | |||
**[[3fga]] – hPP2A catalytic + regulatory subunit + LCMT-1 + SGO<br /> | |||
**[[4i5n]], [[4i5l]] – hPP2A catalytic + regulatory subunit + MCLR<br /> | |||
**[[3k7w]] – hPP2A catalytic + regulatory subunit + toxin<br /> | |||
**[[4iyp]] – hPP2A catalytic subunit + immunoglobin-binding protein<br /> | |||
**[[6ef4]] – mPP2A (mutant) - mouse<br /> | |||
**[[5w0w]] – mPP2A + TIPRL<br /> | |||
*Protein phosphatase 2B See [[Calcineurin]] | *Protein phosphatase 2B See [[Calcineurin]] | ||
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**[[4raf]], [[4rag]] - hPP2C α (mutant) + Mn<br /> | **[[4raf]], [[4rag]] - hPP2C α (mutant) + Mn<br /> | ||
**[[3d8k]] – PP2C – ''Toxoplasma gondii''<br /> | **[[3d8k]] – PP2C – ''Toxoplasma gondii''<br /> | ||
**[[3jrq]], [[3nmn]] – AtPP2C + Pyl1 + pyrabactin | **[[3ujk]] – AtPP2C - ''Arabidopsis thaliana'' <br /> | ||
**[[4yzg]] – AtPP2C (mutant) <br /> | |||
**[[3jrq]], [[3nmn]] – AtPP2C + Pyl1 + pyrabactin <br /> | |||
**[[3kdj]] - AtPP2C + Pyl1 + abscicic acid<br /> | **[[3kdj]] - AtPP2C + Pyl1 + abscicic acid<br /> | ||
**[[3nmt]], [[3kb3]], [[3nmv]], [[3ujl]] – AtPP2C + Pyl2<br /> | **[[3nmt]], [[3kb3]], [[3nmv]], [[3ujl]] – AtPP2C + Pyl2<br /> | ||
**[[4la7]], [[4lg5]], [[4lga]], [[4lgb]] – AtPP2C + Pyl2 + ligand<br /> | **[[4la7]], [[4lg5]], [[4lga]], [[4lgb]] – AtPP2C + Pyl2 + ligand<br /> | ||
**[[5vr7]], [[5vro]], [[5vs5]], [[5vsq]], [[5vsr]], [[5vt7]] – AtPP2C + Pyl2 + quinolone derivative<br /> | |||
**[[4ds8]], [[5jo1]], [[5jo2]] – AtPP2C + Pyl3 + Mn<br /> | **[[4ds8]], [[5jo1]], [[5jo2]] – AtPP2C + Pyl3 + Mn<br /> | ||
**[[3rt0]] – AtPP2C (mutant) + Pyl10<br /> | **[[3rt0]] – AtPP2C (mutant) + Pyl10<br /> | ||
**[[4n0g]] – AtPP2C + Pyl13<br /> | **[[4n0g]] – AtPP2C + Pyl13<br /> | ||
**[[3qn1]], [[3zvu]], [[4wvo]] – AtPP2C + Pyr1<br /> | **[[3qn1]], [[3zvu]], [[4wvo]] – AtPP2C + Pyr1<br /> | ||
**[[ | **[[5or2]], [[5or6]] – AtPP2C + Pyr1 + abscicic acid analog<br /> | ||
**[[4yzh]] – AtPP2C (mutant) + chlorophyll-binding protein peptide<br /> | **[[4yzh]] – AtPP2C (mutant) + chlorophyll-binding protein peptide<br /> | ||
**[[3ujg]] - AtPP2C + SRK2E<br /> | **[[3ujg]] - AtPP2C + SRK2E<br /> | ||
**[[5mn0]] – AtPP2C + ABA receptor <br /> | |||
*Protein phosphatase 4 | *Protein phosphatase 4 | ||
