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'''SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES''' | '''SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES''' | ||
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[[Category: Diederichs, K.]] | [[Category: Diederichs, K.]] | ||
[[Category: Welte, W.]] | [[Category: Welte, W.]] | ||
[[Category: | [[Category: Outer membrane protein]] | ||
[[Category: | [[Category: Porin]] | ||
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Revision as of 06:38, 2 May 2008
SUCROSE-SPECIFIC PORIN, WITH BOUND SUCROSE MOLECULES
Overview
The X-ray structure of a sucrose-specific porin (ScrY) from Salmonella typhimurium has been determined by multiple isomorphous replacement at 2.4 A resolution both in its uncomplexed form and with bound sucrose. ScrY is a noncrystallographic trimer of identical subunits, each with 413 structurally well-defined amino acids. A monomer is built up of 18 anti-parallel beta-strands surrounding a hydrophilic pore, with a topology closely similar to that of maltoporin. Two non-overlapping sucrose-binding sites were identified in difference Fourier maps. The higher permeability for sucrose of ScrY as compared to maltoporin is mainly accounted for by differences in their pore-lining residues.
About this Structure
1A0T is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.
Reference
Structure of the sucrose-specific porin ScrY from Salmonella typhimurium and its complex with sucrose., Forst D, Welte W, Wacker T, Diederichs K, Nat Struct Biol. 1998 Jan;5(1):37-46. PMID:9437428 Page seeded by OCA on Fri May 2 09:38:39 2008
