Sandbox Reserved 1563: Difference between revisions

There are three binding sites within the bateman domain that regulate catalytic activity.  These three sites bind dinucleoside polyphosphates and the affinity for those binded sites increases as activity with IMPDH increases.  Purine dinucleoside polyphosphates compete with Purine mononucleotides within the bateman domain.  This requires the bateman domain to make IMPDH more sensitive to inhibition.  Covalent bonds are broken later in the reaction that allows the system enough energy to complete the process.