6a0f: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 6a0f is ~~ON HOLD until Dec 05 2020~~

==Crystal structure of human protein N-terminal asparagine amidohydrolase (NTAN1) C75S mutant with Asn-Phe-Ala-Ala-Arg peptide==

~~Authors~~: ~~Park~~, J.S., ~~Han~~, B.W.

== Structural highlights ==

<table><tr><td colspan='2'>[[6a0f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A0F FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~human protein~~ N-terminal asparagine ~~amidohydrolase~~ (~~NTAN1~~) ~~C75S mutant with Asn~~-~~Phe~~-~~Ala~~-~~Ala~~-~~Arg peptide~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a0f OCA], [http://pdbe.org/6a0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a0f RCSB], [http://www.ebi.ac.uk/pdbsum/6a0f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a0f ProSAT]</span></td></tr>

[[Category: Park, J.S]]

</table>

[[Category: ~~Han, B.W~~]]

== Function ==

[[http://www.uniprot.org/uniprot/NTAN1_HUMAN NTAN1_HUMAN]] N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.<ref>PMID:21375249</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Han, B W]]

[[Category: Park, J S]]

[[Category: Amidohydrolase]]

[[Category: Complex]]

[[Category: Hydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6a0f is ON HOLD  until Dec 05 2020
+==Crystal structure of human protein N-terminal asparagine amidohydrolase (NTAN1) C75S mutant with Asn-Phe-Ala-Ala-Arg peptide==
+<StructureSection load='6a0f' size='340' side='right'caption='[[6a0f]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
-Authors: Park, J.S., Han, B.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6a0f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A0F FirstGlance]. <br>
-Description: Crystal structure of human protein N-terminal asparagine amidohydrolase (NTAN1) C75S mutant with Asn-Phe-Ala-Ala-Arg peptide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a0f OCA], [http://pdbe.org/6a0f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a0f RCSB], [http://www.ebi.ac.uk/pdbsum/6a0f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a0f ProSAT]</span></td></tr>
-[[Category: Park, J.S]]
+</table>
-[[Category: Han, B.W]]
+== Function ==
+[[http://www.uniprot.org/uniprot/NTAN1_HUMAN NTAN1_HUMAN]] N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.<ref>PMID:21375249</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Han, B W]]
+[[Category: Park, J S]]
+[[Category: Amidohydrolase]]
+[[Category: Complex]]
+[[Category: Hydrolase]]