6iws: Difference between revisions
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==Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein== | |||
<StructureSection load='6iws' size='340' side='right'caption='[[6iws]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6iws]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IWS FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iws OCA], [http://pdbe.org/6iws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iws RCSB], [http://www.ebi.ac.uk/pdbsum/6iws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iws ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Kim, J | == Function == | ||
[[Category: Won, H | [[http://www.uniprot.org/uniprot/DNJA3_HUMAN DNJA3_HUMAN]] Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Jo, K S]] | |||
[[Category: Kim, J H]] | |||
[[Category: Sim, D W]] | |||
[[Category: Won, H S]] | |||
[[Category: Chaperone]] | |||
[[Category: Dnaja3]] | |||
[[Category: Hpd motif]] | |||
[[Category: J-domain]] | |||
[[Category: Mthsp40]] | |||
[[Category: Solution structure]] | |||
[[Category: Tid1]] | |||
Revision as of 15:03, 11 December 2019
Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein
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