6qaf: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The~~ entry ~~6qaf~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of human Arginase-1 at pH 9.0 in complex with CB-1158/INCB001158==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6qaf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QAF OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QAF FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XC3:[(~{E})-3-[(3~{S},4~{R})-4-azanyl-1-[(2~{S})-2-azanylpropanoyl]-4-carboxy-pyrrolidin-3-yl]prop-1-enyl]-tris(oxidanyl)boranium'>XC3</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6q92|6q92]], [[6q9p|6q9p]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qaf OCA], [http://pdbe.org/6qaf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qaf RCSB], [http://www.ebi.ac.uk/pdbsum/6qaf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qaf ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Arginase]]

[[Category: Large Structures]]

[[Category: Grobben, Y]]

[[Category: Tabak, W W.A]]

[[Category: Uitdehaag, J C.M]]

[[Category: Zaman, G J.R]]

[[Category: Arignase inhibitor]]

[[Category: Borate]]

[[Category: Hydrolase]]

[[Category: Manganese cluster]]

[[Category: Ph-dependent]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6qaf is ON HOLD  until Paper Publication
+==Crystal structure of human Arginase-1 at pH 9.0 in complex with CB-1158/INCB001158==
+<StructureSection load='6qaf' size='340' side='right'caption='[[6qaf]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qaf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QAF FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=XC3:[(~{E})-3-[(3~{S},4~{R})-4-azanyl-1-[(2~{S})-2-azanylpropanoyl]-4-carboxy-pyrrolidin-3-yl]prop-1-enyl]-tris(oxidanyl)boranium'>XC3</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6q92|6q92]], [[6q9p|6q9p]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qaf OCA], [http://pdbe.org/6qaf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qaf RCSB], [http://www.ebi.ac.uk/pdbsum/6qaf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qaf ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arginase]]
+[[Category: Large Structures]]
+[[Category: Grobben, Y]]
+[[Category: Tabak, W W.A]]
+[[Category: Uitdehaag, J C.M]]
+[[Category: Zaman, G J.R]]
+[[Category: Arignase inhibitor]]
+[[Category: Borate]]
+[[Category: Hydrolase]]
+[[Category: Manganese cluster]]
+[[Category: Ph-dependent]]