6rhw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6rhw is ~~ON HOLD until Paper Publication~~

==Crystal structure of human CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH==

~~Authors~~: ~~Trstenjak~~, N., ~~Milic~~, D., ~~Djinovic~~-~~Carugo~~, K., ~~Badarau~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[6rhw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RHW FirstGlance]. <br>

~~Description~~: ~~Crystal structure of human CD11b I~~-~~domain (CD11b~~-I) in ~~complex~~ with ~~Staphylococcus aureus octameric bi~~-component ~~leukocidin LukGH~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rhw OCA], [http://pdbe.org/6rhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rhw RCSB], [http://www.ebi.ac.uk/pdbsum/6rhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rhw ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

== Function ==

[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Badarau, A]]

[[Category: Djinovic-Carugo, K]]

~~[[Category: Badarau, A]]~~

[[Category: Milic, D]]

[[Category: Trstenjak, N]]

[[Category: Complex]]

[[Category: Leukocidin]]

[[Category: Octamer]]

[[Category: Pore-forming toxin]]

[[Category: Receptor]]

[[Category: Toxin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6rhw is ON HOLD  until Paper Publication
+==Crystal structure of human CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH==
+<StructureSection load='6rhw' size='340' side='right'caption='[[6rhw]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
-Authors: Trstenjak, N., Milic, D., Djinovic-Carugo, K., Badarau, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rhw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RHW FirstGlance]. <br>
-Description: Crystal structure of human CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rhw OCA], [http://pdbe.org/6rhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rhw RCSB], [http://www.ebi.ac.uk/pdbsum/6rhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rhw ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[http://omim.org/entry/609939 609939]]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
+== Function ==
+[[http://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN]] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Badarau, A]]
 [[Category: Djinovic-Carugo, K]]
-[[Category: Badarau, A]]
 [[Category: Milic, D]]
 [[Category: Trstenjak, N]]
+[[Category: Complex]]
+[[Category: Leukocidin]]
+[[Category: Octamer]]
+[[Category: Pore-forming toxin]]
+[[Category: Receptor]]
+[[Category: Toxin]]