6rhv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6rhv is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of mouse CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH (LukH K319A mutant)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6rhv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RHV FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rhv OCA], [http://pdbe.org/6rhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rhv RCSB], [http://www.ebi.ac.uk/pdbsum/6rhv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rhv ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ITAM_MOUSE ITAM_MOUSE]] Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038).[UniProtKB:P11215]<ref>PMID:18685038</ref> <ref>PMID:8986723</ref> <ref>PMID:9382884</ref> <ref>PMID:9862668</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Badarau, A]]

[[Category: Djinovic-Carugo, K]]

[[Category: Milic, D]]

[[Category: Trstenjak, N]]

[[Category: Complex]]

[[Category: Leukocidin]]

[[Category: Octamer]]

[[Category: Pore-forming toxin]]

[[Category: Receptor]]

[[Category: Toxin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6rhv is ON HOLD  until Paper Publication
+==Crystal structure of mouse CD11b I-domain (CD11b-I) in complex with Staphylococcus aureus octameric bi-component leukocidin LukGH (LukH K319A mutant)==
+<StructureSection load='6rhv' size='340' side='right'caption='[[6rhv]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rhv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RHV FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rhv OCA], [http://pdbe.org/6rhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rhv RCSB], [http://www.ebi.ac.uk/pdbsum/6rhv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rhv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ITAM_MOUSE ITAM_MOUSE]] Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038).[UniProtKB:P11215]<ref>PMID:18685038</ref> <ref>PMID:8986723</ref> <ref>PMID:9382884</ref> <ref>PMID:9862668</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Badarau, A]]
+[[Category: Djinovic-Carugo, K]]
+[[Category: Milic, D]]
+[[Category: Trstenjak, N]]
+[[Category: Complex]]
+[[Category: Leukocidin]]
+[[Category: Octamer]]
+[[Category: Pore-forming toxin]]
+[[Category: Receptor]]
+[[Category: Toxin]]