1wpd: Difference between revisions

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==Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins==

== Structural highlights ==

<table><tr><td colspan='2'>[[1wpd]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Scorpio_maurus_palmatus,_heterometrus_spinifer Scorpio maurus palmatus, heterometrus spinifer]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPD FirstGlance]. <br>

<table><tr><td colspan='2'>[[1wpd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPD FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpd OCA], [http://pdbe.org/1wpd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wpd RCSB], [http://www.ebi.ac.uk/pdbsum/1wpd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpd ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/~~KAX62_SCOMA KAX62_SCOMA~~]] Blocks voltage-gated potassium channels ~~(Shaker B, and~~ Kv1.2/KCNA2 (IC(50)=0.8 nM)) ~~and is also active on~~ Kv1.1/KCNA1 (IC(50)=45 nM) Kv1.3/KCNA3 (IC(50)=180 nM). ~~Also inhibits apamin-sensitive small conductance calcium-activated potassium (SK~~/~~KCNN) channels, and inhibits intermediate conductance calcium-activated potassium (KCa3.1/KCNN4) channels.~~<ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>

[[http://www.uniprot.org/uniprot/KAX62_SCOPA KAX62_SCOPA]] Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.12-0.8 nM), KCa3.1/KCNN4 (IC(50)=1-2.2 nM), Shaker B (IC(50)=2.39-80 nM), Kv1.1/KCNA1 (IC(50)=37-45 or no activity, depending on the study), Kv1.3/KCNA3 (IC(50)=150-180 or no activity, depending on the study).<ref>PMID:10888198</ref> <ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:18042681</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>

== Publication Abstract from PubMed ==

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==See Also==

*[[Potassium channel toxin|Potassium channel toxin]]

*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]

== References ==

__TOC__

</StructureSection>

[[Category: ~~Scorpio maurus palmatus, heterometrus spinifer~~]]

[[Category: Large Structures]]

[[Category: Andreotti, N]]

[[Category: Beeton, C]]

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@@ Line 1: / Line 1: @@
 ==Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins==
-<StructureSection load='1wpd' size='340' side='right' caption='[[1wpd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1wpd' size='340' side='right'caption='[[1wpd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1wpd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Scorpio_maurus_palmatus,_heterometrus_spinifer Scorpio maurus palmatus, heterometrus spinifer]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPD FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1wpd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WPD FirstGlance]. <br>
 </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpd OCA], [http://pdbe.org/1wpd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wpd RCSB], [http://www.ebi.ac.uk/pdbsum/1wpd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpd ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/KAX62_SCOMA KAX62_SCOMA]] Blocks voltage-gated potassium channels (Shaker B, and Kv1.2/KCNA2 (IC(50)=0.8 nM)) and is also active on Kv1.1/KCNA1 (IC(50)=45 nM) Kv1.3/KCNA3 (IC(50)=180 nM). Also inhibits apamin-sensitive small conductance calcium-activated potassium (SK/KCNN) channels, and inhibits intermediate conductance calcium-activated potassium (KCa3.1/KCNN4) channels.<ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>
+[[http://www.uniprot.org/uniprot/KAX62_SCOPA KAX62_SCOPA]] Blocks voltage-gated potassium channels Kv1.2/KCNA2 (IC(50)=0.12-0.8 nM), KCa3.1/KCNN4 (IC(50)=1-2.2 nM), Shaker B (IC(50)=2.39-80 nM), Kv1.1/KCNA1 (IC(50)=37-45 or no activity, depending on the study), Kv1.3/KCNA3 (IC(50)=150-180 or no activity, depending on the study).<ref>PMID:10888198</ref> <ref>PMID:10920011</ref> <ref>PMID:12527813</ref> <ref>PMID:15498765</ref> <ref>PMID:18042681</ref> <ref>PMID:9022673</ref> <ref>PMID:9136903</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 ==See Also==
-*[[Potassium channel toxin|Potassium channel toxin]]
+*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Scorpio maurus palmatus, heterometrus spinifer]]
+[[Category: Large Structures]]
 [[Category: Andreotti, N]]
 [[Category: Beeton, C]]