1a4v: Difference between revisions

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[[Image:1a4v.gif|left|200px]]
[[Image:1a4v.gif|left|200px]]


{{Structure
<!--
|PDB= 1a4v |SIZE=350|CAPTION= <scene name='initialview01'>1a4v</scene>, resolution 1.8&Aring;
The line below this paragraph, containing "STRUCTURE_1a4v", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=CB1:Ca+Binding+Site+In+The+Ca-Binding-Elbow+Region+Is+Referr+...'>CB1</scene> and <scene name='pdbsite=CB2:This+Is+The+Secondary+Ca+Binding+Site.+At+This+Site+The+...'>CB2</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactose_synthase Lactose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.22 2.4.1.22] </span>
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1a4v| PDB=1a4v  | SCENE= }}  
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a4v OCA], [http://www.ebi.ac.uk/pdbsum/1a4v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1a4v RCSB]</span>
}}


'''ALPHA-LACTALBUMIN'''
'''ALPHA-LACTALBUMIN'''
Line 28: Line 25:
[[Category: Acharya, K R.]]
[[Category: Acharya, K R.]]
[[Category: Chandra, N.]]
[[Category: Chandra, N.]]
[[Category: alpha-lactalbumin]]
[[Category: Alpha-lactalbumin]]
[[Category: calcium binding]]
[[Category: Calcium binding]]
[[Category: lactose synthase]]
[[Category: Lactose synthase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 09:48:53 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:33:15 2008''

Revision as of 06:48, 2 May 2008

File:1a4v.gif


Drag the structure with the mouse to rotate
1a4v, resolution 1.80Å (default scene)
Ligands: CA
Activity: Lactose synthase, with EC number 2.4.1.22
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



ALPHA-LACTALBUMIN


Overview

The high-resolution X-ray crystal structure of human alpha-lactalbumin (at 1.8 A) in the presence of an elevated level of calcium reveals a new secondary calcium binding site, 7.9 A away from the primary calcium binding site known in all alpha-lactalbumin structures so far. The new calcium binding site is different from the zinc and sulfate binding sites [Ren, J., et al. (1993) J. Biol. Chem. 268, 19292-19298] but shares common features with the manganese binding site as described by Gerkin [Gerkin, T. A. (1984) Biochemistry 23, 4688-4697]. The proximity of the manganese and calcium binding region and the location of the functional site on one side of the charged surface of the alpha-lactalbumin molecule suggest that these binding sites might play a role in the formation of the lactose synthase complex.

About this Structure

1A4V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:9537992 Page seeded by OCA on Fri May 2 09:48:53 2008

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