6idw: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6idw OCA], [http://pdbe.org/6idw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6idw RCSB], [http://www.ebi.ac.uk/pdbsum/6idw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6idw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6idw OCA], [http://pdbe.org/6idw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6idw RCSB], [http://www.ebi.ac.uk/pdbsum/6idw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6idw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
The catalytic domain (residues 128-449) of the Orpinomyces sp. Y102 CelC7 enzyme (Orp CelC7) exhibits cellobiohydrolase and cellotriohydrolase activities. Crystal structures of Orp CelC7 and its cellobiose-bound complex have been solved at resolutions of 1.80 and 2.78 A, respectively. Cellobiose occupies subsites +1 and +2 within the active site of Orp CelC7 and forms hydrogen bonds to two key residues: Asp248 and Asp409. Furthermore, its substrate-binding sites have both tunnel-like and open-cleft conformations, suggesting that the glycoside hydrolase family 6 (GH6) Orp CelC7 enzyme may perform enzymatic hydrolysis in the same way as endoglucanases and cellobiohydrolases. LC-MS/MS analysis revealed cellobiose (major) and cellotriose (minor) to be the respective products of endo and exo activity of the GH6 Orp CelC7. | |||
Crystal structures of the GH6 Orpinomyces sp. Y102 CelC7 enzyme with exo and endo activity and its complex with cellobiose.,Huang HC, Qi LH, Chen YC, Tsai LC Acta Crystallogr D Struct Biol. 2019 Dec 1;75(Pt 12):1138-1147. doi:, 10.1107/S2059798319013597. Epub 2019 Nov 29. PMID:31793907<ref>PMID:31793907</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 6idw" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Glucanase 3D structures|Glucanase 3D structures]] | *[[Glucanase 3D structures|Glucanase 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
