6jbj: Difference between revisions
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The entry | ==Cryo-EM structure of human lysosomal cobalamin exporter ABCD4== | ||
<StructureSection load='6jbj' size='340' side='right'caption='[[6jbj]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jbj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JBJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | |||
[[Category: | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABCD4, PXMP1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbj OCA], [http://pdbe.org/6jbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jbj RCSB], [http://www.ebi.ac.uk/pdbsum/6jbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbj ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ABCD4_HUMAN ABCD4_HUMAN]] Methylmalonic acidemia with homocystinuria, type cblJ. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ABCD4_HUMAN ABCD4_HUMAN]] May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.<ref>PMID:22922874</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen, Y]] | |||
[[Category: Feng, Z]] | |||
[[Category: Hou, W T]] | |||
[[Category: Jiang, Y L]] | |||
[[Category: Sun, L F]] | |||
[[Category: Wang, L]] | |||
[[Category: Xu, D]] | |||
[[Category: Zhou, C Z]] | |||
[[Category: Atp-bound]] | |||
[[Category: Human abcd4]] | |||
[[Category: Lysosomal cobalamin exporter]] | |||
[[Category: Lysosome-open conformation]] | |||
[[Category: Membrane protein]] | |||
Revision as of 10:47, 18 December 2019
Cryo-EM structure of human lysosomal cobalamin exporter ABCD4
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