6l8u: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry 6l8u~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of human BCDIN3D in complex with SAH==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6l8u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L8U FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l8u OCA], [http://pdbe.org/6l8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l8u RCSB], [http://www.ebi.ac.uk/pdbsum/6l8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l8u ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BN3D2_HUMAN BN3D2_HUMAN]] O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme (PubMed:28119416). Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs (PubMed:23063121). There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA (PubMed:23063121, PubMed:28119416, PubMed:30127802).<ref>PMID:23063121</ref> <ref>PMID:28119416</ref> <ref>PMID:30127802</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Liu, Y]]

[[Category: Martinez, A]]

[[Category: Tomita, K]]

[[Category: Yamashita, S]]

[[Category: Methyltransferase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6l8u is ON HOLD  until Paper Publication
+==Crystal structure of human BCDIN3D in complex with SAH==
+<StructureSection load='6l8u' size='340' side='right'caption='[[6l8u]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6l8u]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L8U FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l8u OCA], [http://pdbe.org/6l8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l8u RCSB], [http://www.ebi.ac.uk/pdbsum/6l8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l8u ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BN3D2_HUMAN BN3D2_HUMAN]] O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme (PubMed:28119416). Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs (PubMed:23063121). There is some controversy about the methylation of pre-miR-145, since the dimethylation first described as the specific enzymatic activity cannot be reproduced by a more recent work which observes a monomehtylation of pre-miR-145 but two orders weaker than the methylation of cytosolic histidyl tRNA (PubMed:23063121, PubMed:28119416, PubMed:30127802).<ref>PMID:23063121</ref> <ref>PMID:28119416</ref> <ref>PMID:30127802</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Liu, Y]]
+[[Category: Martinez, A]]
+[[Category: Tomita, K]]
+[[Category: Yamashita, S]]
+[[Category: Methyltransferase]]
+[[Category: Transferase]]