5cbg

Calcium activated non-selective cation channel

spinqualitylabelsall models 5cbg, resolution 3.14Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cbg is a 6 chain structure with sequence from Corynebacterium paurometabolum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, DMU Related: 5cbf, 5cbh Gene: Tpau_1687 (Corynebacterium paurometabolum) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The selectivity filter is an essential functional element of K(+) channels that is highly conserved both in terms of its primary sequence and its three-dimensional structure. Here, we investigate the properties of an ion channel from the Gram-positive bacterium Tsukamurella paurometabola with a selectivity filter formed by an uncommon proline-rich sequence. Electrophysiological recordings show that it is a non-selective cation channel and that its activity depends on Ca(2+) concentration. In the crystal structure, the selectivity filter adopts a novel conformation with Ca(2+) ions bound within the filter near the pore helix where they are coordinated by backbone oxygen atoms, a recurrent motif found in multiple proteins. The binding of Ca(2+) ion in the selectivity filter controls the widening of the pore as shown in crystal structures and in molecular dynamics simulations. The structural, functional and computational data provide a characterization of this calcium-gated cationic channel. Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.,Dhakshnamoorthy B, Rohaim A, Rui H, Blachowicz L, Roux B Nat Commun. 2016 Sep 28;7:12753. doi: 10.1038/ncomms12753. PMID:27678077 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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