5et3: Difference between revisions
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==Crystal Structure of De novo Designed Fullerene organizing peptide== | ==Crystal Structure of De novo Designed Fullerene organizing peptide== | ||
<StructureSection load='5et3' size='340' side='right' caption='[[5et3]], [[Resolution|resolution]] 1.67Å' scene=''> | <StructureSection load='5et3' size='340' side='right'caption='[[5et3]], [[Resolution|resolution]] 1.67Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5et3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ET3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ET3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[5et3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ET3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ET3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=60C:(C_{60}-I_{H})[5,6]FULLERENE'>60C</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=60C:(C_{60}-I_{H})[5,6]FULLERENE'>60C</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5et3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5et3 OCA], [http://pdbe.org/5et3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5et3 RCSB], [http://www.ebi.ac.uk/pdbsum/5et3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5et3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5et3 OCA], [http://pdbe.org/5et3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5et3 RCSB], [http://www.ebi.ac.uk/pdbsum/5et3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5et3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Learning to engineer self-assembly would enable the precise organization of molecules by design to create matter with tailored properties. Here we demonstrate that proteins can direct the self-assembly of buckminsterfullerene (C60) into ordered superstructures. A previously engineered tetrameric helical bundle binds C60 in solution, rendering it water soluble. Two tetramers associate with one C60, promoting further organization revealed in a 1.67-A crystal structure. Fullerene groups occupy periodic lattice sites, sandwiched between two Tyr residues from adjacent tetramers. Strikingly, the assembly exhibits high charge conductance, whereas both the protein-alone crystal and amorphous C60 are electrically insulating. The affinity of C60 for its crystal-binding site is estimated to be in the nanomolar range, with lattices of known protein crystals geometrically compatible with incorporating the motif. Taken together, these findings suggest a new means of organizing fullerene molecules into a rich variety of lattices to generate new properties by design. | |||
Protein-directed self-assembly of a fullerene crystal.,Kim KH, Ko DK, Kim YT, Kim NH, Paul J, Zhang SQ, Murray CB, Acharya R, DeGrado WF, Kim YH, Grigoryan G Nat Commun. 2016 Apr 26;7:11429. doi: 10.1038/ncomms11429. PMID:27113637<ref>PMID:27113637</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5et3" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Acharya, R]] | [[Category: Acharya, R]] | ||
[[Category: DeGrado, W F]] | [[Category: DeGrado, W F]] | ||
Revision as of 11:35, 25 December 2019
Crystal Structure of De novo Designed Fullerene organizing peptide
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