5i90

Crystal Structure of PvdN from Pseudomonas Aeruginosa

spinqualitylabelsall models 5i90, resolution 1.22Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5i90 is a 2 chain structure with sequence from Pseae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EDO, PLP Gene: pvdN, PA2394 (PSEAE) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The Gram-negative pathogen Pseudomonas aeruginosa uses a nonribosomal peptide synthetase (NRPS) biosynthetic cluster for the production of a peptide siderophore. In addition to four multimodular NRPS proteins, the biosynthetic pathway also requires several additional enzymes involved in the production of nonproteinogenic amino acids and maturation of the peptide product. Among the proteins that are required for the final steps in pyoverdine synthesis is PvdN, a pyridoxal phosphate-dependent enzyme that catalyzes an uncharacterized step in pyoverdine production. This study reports the high-resolution structure of PvdN bound to a PLP cofactor solved by multi-wavelength anomalous dispersion (MAD). The PvdN model shows high structural homology to type I aspartate aminotransferases and also contains positive density that suggests an uncharacterized external aldimine. 1.2 A resolution crystal structure of the periplasmic aminotransferase PvdN from Pseudomonas aeruginosa.,Drake EJ, Gulick AM Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):403-8. doi:, 10.1107/S2053230X16006257. Epub 2016 Apr 22. PMID:27139833 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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