5iy0

PfMCM N-terminal domain double hexamer

spinqualitylabelsall models 5iy0, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5iy0 is a 6 chain structure with sequence from Pyrfu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Gene: PF0482 (PYRFU) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The crystal structure of the N-terminal domain of the Pyrococcus furiosus minichromosome maintenance (MCM) protein as a double hexamer is described. The MCM complex is a ring-shaped helicase that unwinds DNA at the replication fork of eukaryotes and archaea. Prior to replication initiation, the MCM complex assembles as an inactive double hexamer at specific sites of DNA. The presented structure is highly consistent with previous MCM double-hexamer structures and shows two MCM hexamers with a head-to-head interaction mediated by the N-terminal domain. Minor differences include a diminished head-to-head interaction and a slightly reduced inter-hexamer rotation. Structure of a double hexamer of the Pyrococcus furiosus minichromosome maintenance protein N-terminal domain.,Meagher M, Enemark EJ Acta Crystallogr F Struct Biol Commun. 2016 Jul 1;72(Pt 7):545-51. doi:, 10.1107/S2053230X1600858X. Epub 2016 Jun 22. PMID:27380371 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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