4zdr

Crystal structure of 14-3-3[zeta]-LKB1 fusion protein

spinqualitylabelsall models 4zdr, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4zdr is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, SO4, TME Gene: STK11, LKB1, PJS (HUMAN) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [1433Z_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Publication Abstract from PubMed The 14-3-3 proteins are a family of highly conserved proteins that play key roles in many cellular processes. The tumour suppressor LKB1 regulates cell polarity, cell growth and energy metabolism. 14-3-3 proteins bind to LKB1 and suppress its functions. Previously, preliminary crystallographic data for the 14-3-3zeta-LKB1 fusion protein have been reported. Here, the crystal structure of this fusion protein was solved and a novel potential binding mode of 14-3-3 to its ligands was found. Structure of the 14-3-3zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3.,Ding S, Zhou R, Zhu Y Acta Crystallogr F Struct Biol Commun. 2015 Sep;71(Pt 9):1114-9. doi:, 10.1107/S2053230X15012595. Epub 2015 Aug 25. PMID:26323294 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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