Sandbox Reserved 1099: Difference between revisions
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{{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
'''Dermcidin''' is a '''Human''' [https://en.wikipedia.org/wiki/Antimicrobial_peptides_ antimicrobial peptide] presents in sweat involved in the regulation of skin flora. This molecule encoded by the ''DCD gene'' plays a role in the host defense system and more precisely in the [https://en.wikipedia.org/wiki/Innate_immune_system_ innate immune system] and thus, is able to prevent microbial growth after injuries or any skin disorders. | '''Dermcidin''' is a '''Human''' [https://en.wikipedia.org/wiki/Antimicrobial_peptides_ antimicrobial peptide] of 109 amino acids presents in sweat involved in the regulation of skin flora. This molecule encoded by the ''DCD gene'' plays a role in the host defense system and more precisely in the [https://en.wikipedia.org/wiki/Innate_immune_system_ innate immune system] and thus, is able to prevent microbial growth after injuries or any skin disorders. | ||
== Expression and function == | == Expression and function == | ||
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*[https://fr.wikipedia.org/wiki/Défensine_ Defensins] which are cationic peptides (α-defensins and β-defensins) | *[https://fr.wikipedia.org/wiki/Défensine_ Defensins] which are cationic peptides (α-defensins and β-defensins) | ||
Dermcidin gene is expressed as precursor only in eccrine sweat glands within the dermis of the skin and the derived-peptide is secreted by granules. | Dermcidin gene is expressed as precursor only in mucous cells of eccrine sweat glands within the dermis of the skin and the derived-peptide is secreted by granules in sweat. The active also named DCD-1 form contains the end C-terminal from the 62 to the 109 residue and is probably created by proteases in sweat. | ||
Then, | |||
== Structural highlights == | == Structural highlights == | ||