Sandbox Reserved 1098: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 44: | Line 44: | ||
== Diseases and Relevance == | == Diseases and Relevance == | ||
Due to the function of the protein poly (ADP-ribose) glycohydrolase PARG to be part of post-translational processes of DNA damage repair it could be used for new treatments in cancer therapy or for ther diseases. In cancer cells the rate of DNA damaging is most probably higher than in normal cells. This could result from the considerably raised stress levels. A deficiency of PARG results in the cessing of the cell cycle and the following cell death. Consequently, the inhibition of PARG might be a solution how to destroy for example tumour cells. | |||
For the opponent PAR protein there has already been a lot of research in this field but not for PARG. As there are no close homologues of PARG, this protein provides a potential target in drug discovery. | |||
As the protein in complex with the anthraquinone does not work properly anymore, the described complex shows how an inhibited PARG might act in the cell. The goal of searched therapeutics is therefore to find a way to get the protein PARG into a complex that is acting like the 6HMM complex. For now the research for anthraquinone as inhibitor has stopped as it is cytotoxic for the cell. | |||
