Sandbox Reserved 1104: Difference between revisions
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Multicopper oxidases are enzymes which oxidise their substrate by accepting electrons at a mononuclear copper centre and transferring them to a trinuclear copper centre.<ref>Wikipedia, Multicopper oxidase [https://en.wikipedia.org/wiki/Multicopper_oxidase]</ref> | Multicopper oxidases are enzymes which oxidise their substrate by accepting electrons at a mononuclear copper centre and transferring them to a trinuclear copper centre.<ref>Wikipedia, Multicopper oxidase [https://en.wikipedia.org/wiki/Multicopper_oxidase]</ref> | ||
Bilirubin oxidases are multicopper oxidases containing type 1, type 2, and type 3 coppers. Indeed, there is strong sequence homology between bilirubin oxidase and multicopper oxidases like laccase, ascorbate oxidase and even ceruloplasmin. Moreover, the His-Cys-His sequence, characteristic of multicopper oxidase, is present in bilirubin oxidase. Copper is essential for the enzyme activity.<ref name="multic">Atsushi Shimizu, ''Myrothecium verrucaria'' Bilirubin Oxidase and Its Mutants for Potential Copper Ligands (1999)[https://doi.org/10.1021/bi9819531]</ref> | Bilirubin oxidases are multicopper oxidases containing type 1, type 2, and type 3 coppers. Indeed, there is strong sequence homology between bilirubin oxidase and multicopper oxidases like laccase, ascorbate oxidase and even ceruloplasmin. Moreover, the His-Cys-His sequence, characteristic of multicopper oxidase, is present in bilirubin oxidase. Copper is essential for the enzyme activity.<ref name="multic">Atsushi Shimizu, Jung-Hee Kwon, Takashi Sasaki, Takanori Satoh, Nobuhiko Sakurai, Takeshi Sakurai, Shotaro Yamaguchi, Tatsuya Samejima, ''Myrothecium verrucaria'' Bilirubin Oxidase and Its Mutants for Potential Copper Ligands (1999)[https://doi.org/10.1021/bi9819531]</ref> | ||
== Function == | == Function == | ||
