Sandbox Reserved 1105: Difference between revisions
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== TTR transport functions == | == TTR transport functions == | ||
Human transthyretin (TTR) ([[4tlt]]) is a highly conserved homotetrameric transport protein. Identified in 1942, it was originally called prealbumin as it runs faster than albumin ([[1bm0]]) during SDS-PAGE [1]. After discovering its binding ability to thyroid hormones, it was given the name of “thyroxine-binding prealbumin” (TBPA). Finally, its actual name refers to an additional carrier function: '''trans'''ports '''thyr'''oxine (T4) and '''ret'''inol (vitamin A). | Human transthyretin (TTR) ([[4tlt]]) is a highly conserved homotetrameric transport protein. Identified in 1942, it was originally called prealbumin as it runs faster than albumin ([[1bm0]]) during SDS-PAGE [1]. After discovering its binding and transport ability to thyroid hormones, it was given the name of “thyroxine-binding prealbumin” (TBPA). Finally, its actual name refers to an additional carrier function: '''trans'''ports '''thyr'''oxine (T4) and '''ret'''inol (vitamin A). | ||
It is mainly present in the plasma and synthetized by the liver, but also in the cerebrospinal fluid produced by the choroid plexus of the brain, and in retinal pigment epithelium. | It is mainly present in the plasma and synthetized by the liver, but also in the cerebrospinal fluid produced by the choroid plexus of the brain, and in retinal pigment epithelium. | ||
