Sandbox Reserved 1093: Difference between revisions
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LRRTM2 is a transmembrane protein that can be found in human neurons. It functions as postsynaptic organizers that induce excitatory synapses. LRRTM2 is prominently expressed in deep layers, rather than superficial layers, of the cerebral cortex. LRRTM2 specifically localizes in excitatory synapses, and not in inhibitory synapses. In addition, LRRTMs interact with neurexins, a well-known family of presynaptic adhesion molecules to bridge the synaptic cleft. | |||
== Structural highlights == | == Structural highlights == | ||
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The X-ray structure of LRRTM2 reveals that this transmembrane protein is composed of 3 main domains: a N-terminal leucine rich repeat domain which is extracellular, a single transmembrane domain and a C-terminal cytoplasmic region. The protein is composed of 516 amino acids. | The X-ray structure of LRRTM2 reveals that this transmembrane protein is composed of 3 main domains: a N-terminal leucine rich repeat domain which is extracellular, a single transmembrane domain and a C-terminal cytoplasmic region. The protein is composed of 516 amino acids. | ||
[[Image:LRRTM2 details.png|900px|left]] | |||
1) <scene name='82/829346/Lrrtm2/3'>N-term fixation domain</scene> | 1) <scene name='82/829346/Lrrtm2/3'>N-term fixation domain</scene> | ||
