Sandbox Reserved 1095: Difference between revisions
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=== Recent studies === | === Recent studies === | ||
Finally, around 2015, researchers have found the crystal structure of the receptor in complex with its antagonist [https:// | Finally, around 2015, researchers have found the crystal structure of the receptor in complex with its antagonist [https://pubchem.ncbi.nlm.nih.gov/compound/ZD-7155-hydrochloride ZD7155] and with an inverse agonist [https://en.wikipedia.org/wiki/Olmesartan olmesartan]<ref> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705918/ </ref>. [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray cryogenic-crystallography] has been used. They have found similar conformation of the receptor when it is linked to the antagonist or to the inverse agonist. They have also found conserved molecular recognition modes. To complete this discovery, they have realized some experiments with mutants to identify the different residues which interact with the ligand. | ||
The structure of this protein have also been solved using an other method called serial femtosecond crystallography, corresponding to the proteopedia page [http://proteopedia.org/wiki/index.php/4yay 4YAY]. | The structure of this protein have also been solved using an other method called serial femtosecond crystallography, corresponding to the proteopedia page [http://proteopedia.org/wiki/index.php/4yay 4YAY]. | ||
