Sandbox Reserved 1099: Difference between revisions

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Dermcidin gene is located on the '''chromosome 12''' and constitutively expressed as '''precursor''' only in mucous cells of eccrine sweat glands within the dermis of the skin. The derived-peptide is then secreted by granules in sweat.

The molecular weight of the DCD full-length sequence (110 amino acids) is 9,3 kDa including the signal peptide. In that way, many DCD forms could be proteolytically processed. But the most abundant DCD peptide presents in sweat is '''DCD-1L'''.

DCD-1L contains the C-terminal end from the 63 to the 110 residue. This peptide is probably created by combination of proteases in sweat. The cathepsin D, 1,10-phenthroline-sensitive carboxypeptidase and an endoprotease are involved in the post-secretory processing of DCD-1L <ref>[[ J. Biol. Chem.-2006-Baechle-5406-15]], </ref>.

The Dermcidin peptide sequence has no homology with other known antimicrobial peptides. Two classes of mammalian antimicrobial peptides exist :

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But, some size and structural similarities can be found with the defensin family.

The molecular weight of the DCD full-length sequence (110 amino acids) is 9,3 kDa including the signal peptide. In that way, many DCD forms could be proteolytically processed. But the most abundant DCD peptide presents in sweat is '''DCD-1L'''.

DCD-1L contains the C-terminal end from the 63 to the 110 residue. This peptide is probably created by combination of proteases in sweat. The cathepsin D, 1,10-phenthroline-sensitive carboxypeptidase and an endoprotease are involved in the post-secretory processing of DCD-1L <ref>[[ J. Biol. Chem.-2006-Baechle-5406-15]], </ref>.

== Structural highlights ==

Sandbox Reserved 1099: Difference between revisions

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@@ Line 8: / Line 8: @@
 Dermcidin gene is located on the '''chromosome 12''' and constitutively expressed as '''precursor''' only in mucous cells of eccrine sweat glands within the dermis of the skin. The derived-peptide is then secreted by granules in sweat.
-The molecular weight of the DCD full-length sequence (110 amino acids) is 9,3 kDa including the signal peptide. In that way, many DCD forms could be proteolytically processed. But the most abundant DCD peptide presents in sweat is '''DCD-1L'''.
-DCD-1L contains the C-terminal end from the 63 to the 110 residue. This peptide is probably created by combination of proteases in sweat. The cathepsin D, 1,10-phenthroline-sensitive carboxypeptidase and an endoprotease are involved in the post-secretory processing of DCD-1L <ref>[[ J. Biol. Chem.-2006-Baechle-5406-15]], </ref>.
 The Dermcidin peptide sequence has no homology with other known antimicrobial peptides. Two classes of mammalian antimicrobial peptides exist :
@@ Line 18: / Line 14: @@
 But, some size and structural similarities can be found with the defensin family.
+The molecular weight of the DCD full-length sequence (110 amino acids) is 9,3 kDa including the signal peptide. In that way, many DCD forms could be proteolytically processed. But the most abundant DCD peptide presents in sweat is '''DCD-1L'''.
+DCD-1L contains the C-terminal end from the 63 to the 110 residue. This peptide is probably created by combination of proteases in sweat. The cathepsin D, 1,10-phenthroline-sensitive carboxypeptidase and an endoprotease are involved in the post-secretory processing of DCD-1L <ref>[[ J. Biol. Chem.-2006-Baechle-5406-15]], </ref>.
 == Structural highlights ==