Sandbox Reserved 1099: Difference between revisions
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== Expression == | == Expression == | ||
Dermcidin gene is located on the '''chromosome 12''' and constitutively expressed as '''precursor''' only in mucous cells of eccrine sweat glands within the dermis of the skin. The derived-peptide is then secreted by granules in sweat. | Dermcidin gene is located on the '''chromosome 12''' and constitutively expressed as '''precursor''' only in mucous cells of eccrine sweat glands within the dermis of the skin. The derived-peptide is then secreted by granules in sweat. <ref>Birgit Schittek, Rainer Hipfel, Birgit Sauer, Jürgen Bauer, Hubert Kalbacher, Stefan Stevanovic, Markus Schirle, Kristina Schroeder, Nikolaus Blin, Friedegund Meier, Gernot Rassner & Claus Garbe : Dermcidin: a novel human antibiotic peptide secreted by sweat glands</ref> | ||
The Dermcidin peptide sequence has no homology with other known antimicrobial peptides. Two classes of mammalian antimicrobial peptides exist : | The Dermcidin peptide sequence has no homology with other known antimicrobial peptides. Two classes of mammalian antimicrobial peptides exist : | ||
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== Structural highlights == | == Structural highlights == | ||
Dermcidin is an '''anionic channel''' composed of 6 DCD peptides or 3 antiparallel peptide dimers, and has a dimension of about 8x4 nm. | Dermcidin is an '''anionic channel''' composed of 6 DCD peptides or 3 antiparallel peptide dimers, and has a dimension of about 8x4 nm. <ref>Song, C. et al. : Crystal Structure and Functional Mechanism of a Human Antimicrobial Membrane Channel. PNAS. 2013 [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607029/#!po=50.0000]]</ref> | ||
* Monomer : | * Monomer : | ||
