Sandbox Reserved 1103: Difference between revisions

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The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerizes to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref>PMID: 18202258</ref> . TIN2 or [https://en.wikipedia.org/wiki/TINF2 TINF2] (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or TRF2. This link will regulated their activity and can also stabilize TRF1’s interaction with DNA.  
The TRFH (telomeric repeat factor homology [[1h6o]]) domain is essential to the TRF1 because it’s the sequence where the protein dimerizes to form a functional homodimer. Then, the protein can interact with DNA by fixing to the repeated sequence TTAGGG, and can then remodel DNA. This activity of remodeling is enhanced by the TIN2<ref>PMID: 18202258</ref> . TIN2 or [https://en.wikipedia.org/wiki/TINF2 TINF2] (TERF1 interacting nuclear factor 2) is also a protein of the Shelterin that can bind to TRF1. It acts as a bridge or a link between TRF1 and TPP or TRF2. This link will regulated their activity and can also stabilize TRF1’s interaction with DNA.  
When TIN2 is mutated, telomeres are no longer regulated. TRF1 alone doesn’t seems to be efficient to regulate [[Telomerase]].  
When TIN2 is mutated, telomeres are no longer regulated. TRF1 alone doesn’t seems to be efficient to regulate [[Telomerase]].  
Because of their function in telomeres regulation, TRF1 TIN2 are keys proteins involved in cell aging and their dysfunction can directly leads to disease like cancer or other cell cycle diseases.  
Because of their function in telomeres regulation, TRF1 TIN2 are key proteins involved in cell aging and their dysfunction can directly leads to disease like cancer or other cell cycle diseases.  


<ref group="xtra">PMID: 10669743</ref><ref group="xtra">PMID: 16166375</ref><ref group="xtra">PMID: 30352022</ref><ref group="xtra">PMID: 31026066</ref>
<ref group="xtra">PMID: 10669743</ref><ref group="xtra">PMID: 16166375</ref><ref group="xtra">PMID: 30352022</ref><ref group="xtra">PMID: 31026066</ref>
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