Sandbox Reserved 1102: Difference between revisions
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An increased risk of neurologic complications is associated with Zika virus infection in adults and children, including [https://en.wikipedia.org/wiki/Guillain–Barré_syndrome Guillain-Barré syndrome], [https://en.wikipedia.org/wiki/Peripheral_neuropathy neuropathy ] and [https://en.wikipedia.org/wiki/Myelitis myelitis]. Infection during first trimester of pregnancy can cause [https://en.wikipedia.org/wiki/Microcephaly microcephaly] in newborn children. | An increased risk of neurologic complications is associated with Zika virus infection in adults and children, including [https://en.wikipedia.org/wiki/Guillain–Barré_syndrome Guillain-Barré syndrome], [https://en.wikipedia.org/wiki/Peripheral_neuropathy neuropathy ] and [https://en.wikipedia.org/wiki/Myelitis myelitis]. Infection during first trimester of pregnancy can cause [https://en.wikipedia.org/wiki/Microcephaly microcephaly] in newborn children. | ||
Like all viruses, zika virus needs to express itself in his host. The helicase permits the unwinding of the DNA, and finally the virus replication. | |||
It is the non-structural protein 3 (NS3) of the helicase, that is involved in ATP hydrolysis, RNA unwinding and that provides the conditions for RNA polymerization and methylation of RNA which ZIKV needs for replication. | |||
== Relevance == | == Relevance == | ||
