Sandbox Reserved 1101: Difference between revisions
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== Global structure of the ''N. Clavipes'' Spidroin-1 == | |||
==Global structure of the ''N. Clavipes'' Spidroin-1== | |||
== Monomer structure of the spidroin NTD domain == | == Monomer structure of the spidroin NTD domain == | ||
<Structure load='5iz2' size='350' frame='true' align='right' caption='NTD monomer' scene='Insert optional scene name here' /> | |||
One monomer of NTD (N-Terminal Domain) is composed of 5 [https://en.wikipedia.org/wiki/Alpha_helix_ α-helix] (H1 to H5). | One monomer of NTD (N-Terminal Domain) is composed of 5 [https://en.wikipedia.org/wiki/Alpha_helix_ α-helix] (H1 to H5). | ||
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Compared with spidroin of other species of spider, the 2 subunits (A and B) of the dimerized NTD of the spidroin produced by ''N. Clavipes'' are slightly different, due to a different helices arrangement. So they do not completely overlap. This allows the creation of new intermolecular contact networks. There is also a chain Z composed of 3 amino acids (Ser, Tyr, Gly), but it role is not well established yet. | Compared with spidroin of other species of spider, the 2 subunits (A and B) of the dimerized NTD of the spidroin produced by ''N. Clavipes'' are slightly different, due to a different helices arrangement. So they do not completely overlap. This allows the creation of new intermolecular contact networks. There is also a chain Z composed of 3 amino acids (Ser, Tyr, Gly), but it role is not well established yet. | ||
== Dimerization of the spidroin by the NTD domain == | |||
==Dimerization of the spidroin by the NTD domain== | |||
====Conformational change of the five-helix bundle==== | ====Conformational change of the five-helix bundle==== | ||
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====Interactions==== | ====Interactions==== | ||
<StructureSection load='5IZ2' size='350' frame='true' align='right' caption='N-Terminale domain dimer' scene='Insert optional scene name here' /> | |||
* ''Principal interactions'' | * ''Principal interactions'' | ||