Sandbox Reserved 1091: Difference between revisions
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The '''structure of ASP''' is very similar to that of ''Kex2'' ([[1r64]]), but it has a unique extra-occluding region close to its active site within the subtilisin domains. This extra-occluding region is unique and it could serve as a useful target to make the development of new antisepsis drugs easier. | The '''structure of ASP''' is very similar to that of ''Kex2'' ([[1r64]]), but it has a unique extra-occluding region close to its active site within the subtilisin domains. This extra-occluding region is unique and it could serve as a useful target to make the development of new antisepsis drugs easier. | ||
The '''domain structure of ASP''' consists of the propeptide, the catalytic subtilisin-like domain, and the P-domain. The ASP molecule have two mean regions: an N-terminal region extending from Gly-3 to Pro-431 and forming '' | The '''domain structure of ASP''' consists of the propeptide, the catalytic subtilisin-like domain, and the P-domain. The ASP molecule have two mean regions: an N-terminal region extending from Gly-3 to Pro-431 and forming the <scene name='82/829344/The_subtilisin_domain/1'>subtilisin domain</scene>, and a C-terminal region extending from Leu-432 to His-595 and forming '''the P-domain'''. | ||
Moreover, we can find three '''Ca2+ Binding Sites''' in the ASP Structure (Ca1, Ca2 and Ca3). Ca1 and Ca2 are situated in the N-terminal domain, and Ca3 is situated in the C-terminal domain. It were assigned to ASP based on electron density, counter charges, and coordination. But in contrary to ''Kex2'', ASP contains no Ca2 binding sites near its catalytic site. Those Ca2+ binding Site are important because ... | Moreover, we can find three '''Ca2+ Binding Sites''' in the ASP Structure (Ca1, Ca2 and Ca3). Ca1 and Ca2 are situated in the N-terminal domain, and Ca3 is situated in the C-terminal domain. It were assigned to ASP based on electron density, counter charges, and coordination. But in contrary to ''Kex2'', ASP contains no Ca2 binding sites near its catalytic site. Those Ca2+ binding Site are important because ... | ||
