Sandbox Reserved 1094: Difference between revisions
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==Glucose-6-Phosphate Dehydrogenase from Leuconostoc ''mesenteroides''== | ==Glucose-6-Phosphate Dehydrogenase from Leuconostoc ''mesenteroides''== | ||
<StructureSection load='1dpg' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1dpg' size='340' side='right' caption='Caption for this structure' scene=''> | ||
The protein Glucose-6-Phosphate Dehydrogenase is an enzyme involved in the metabolic pathways of the majority of organisms. Leuconostoc ''mesenteroides'' is a Bacilli Gram-positive bacterium that expresses this enzyme. | The protein''' Glucose-6-Phosphate Dehydrogenase''' is an enzyme involved in the metabolic pathways of the majority of organisms. Leuconostoc ''mesenteroides'' is a Bacilli Gram-positive bacterium that expresses this enzyme. | ||
== Function == | == Function == | ||
G6PD plays an important role in the metabolism of L.''mesenteroides''. | '''G6PD''' plays an important role in the metabolism of L.''mesenteroides''. | ||
Leuconostoc ''mesenteroides'' is a facultactively anaerobic micro-organism which metabolizes glucose to generate lactic acid, ethanol but also carbon dioxyde. | Leuconostoc ''mesenteroides'' is a facultactively anaerobic micro-organism which metabolizes glucose to generate lactic acid, ethanol but also carbon dioxyde. | ||
This glucose metabolic process (glycolysis and pentose phosphate pathway) is catalysed by G6PD. During this process, [[NADH]] is synthesised and used in the heterolactic fermentation and the biosynthesis of fatty acids. | This glucose metabolic process (glycolysis and pentose phosphate pathway) is catalysed by '''G6PD'''. During this process, [[NADH]] is synthesised and used in the heterolactic fermentation and the biosynthesis of fatty acids. | ||
The protein G6PD also has a role in protecting cells from destruction as it produces the co-factor NADPH which plays a role in protecting cells from reactive oxygen species <ref>PMID: 20608171</ref>. | The protein '''G6PD''' also has a role in protecting cells from destruction as it produces the co-factor NADPH which plays a role in protecting cells from reactive oxygen species <ref>PMID: 20608171</ref>. | ||
== Genomic context == | == Genomic context == | ||
It is coded by the G6PD gene (1461 nucleotides)<ref>GeneID:29577449</ref>. | It is coded by the '''G6PD''' gene (1461 nucleotides)<ref>GeneID:29577449</ref>. | ||
It has in total 2 chains. In the link below, these two chains are represented by one unique sequence entity. | It has in total 2 chains. In the link below, these two chains are represented by one unique sequence entity. | ||
Click on | Click on [https://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1DPG] to see the graphical representation. | ||
== Catalytic activity == | == Catalytic activity == | ||
