Sandbox Reserved 1094: Difference between revisions
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It is coded by the '''G6PD''' gene (1461 nucleotides)<ref>GeneID:29577449</ref>. | It is coded by the '''G6PD''' gene (1461 nucleotides)<ref>GeneID:29577449</ref>. | ||
It has in total 2 chains. In the link below, these two chains are represented by one unique sequence entity. | It has in total 2 chains. In the link below, these two chains are represented by one unique sequence entity. | ||
External resource : click on [https://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=1DPG] to see the graphical representation. | |||
== Catalytic activity == | == Catalytic activity == | ||
D-glucose 6-phosphate + NAD+ → 6-phospho-D-glucono-1,5-lactone + H+ + NADH<ref>PMID: 9485426</ref> | D-glucose 6-phosphate + NAD+ → 6-phospho-D-glucono-1,5-lactone + H+ + NADH<ref>PMID: 9485426</ref> | ||
KM=114 µM for G6PD (with NADP), KM=69 µM for G6PD (with NAD), | KM=114 µM for '''G6PD''' (with NADP), KM=69 µM for '''G6PD''' (with NAD), | ||
KM=8.0 µM for NADP, KM=160 µM for NAD. | KM=8.0 µM for [[NADP]], KM=160 µM for NAD. | ||
Its regulation depends on the concentration of substrate and coenzyme, rate limiting step in pentose phosphate pathway<ref>PMID: 12033926</ref>. | Its regulation depends on the concentration of substrate and coenzyme, rate limiting step in pentose phosphate pathway<ref>PMID: 12033926</ref>. | ||
