Sandbox Reserved 110: Difference between revisions
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== Introduction == | == Introduction == | ||
'''MraY''', called also '''phospho-N-acetylmuramoyl-pentapeptide-transferase''' or '''UDP-MurNAc-pentapeptide phosphotransferase''', is an integral membrane enzyme involved in peptidoglycan biosynthesis <ref name="one">PMID:29778697</ref> <ref name="two">PMID:27511599</ref>.MraY is encoded by the mraY gene and belongs to a subfamily of the polyprenyl-phosphate N-acetyl hexosamine 1-phosphate transferase (PNPT) superfamily <ref name="three">PMID:23990562</ref>. MRAY is a promising candidate for the development of new antibiotics. In fact, it is the target of five classes of natural nucleoside inhibitors with potent antibacterial activity <ref name="two"/> <ref name="four">PMID:29438582</ref>. | '''MraY''', called also '''phospho-N-acetylmuramoyl-pentapeptide-transferase''' or '''UDP-MurNAc-pentapeptide phosphotransferase''', with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.13 2.7.8.13], is an integral membrane enzyme involved in peptidoglycan biosynthesis <ref name="one">PMID:29778697</ref> <ref name="two">PMID:27511599</ref>.MraY is encoded by the mraY gene and belongs to a subfamily of the polyprenyl-phosphate N-acetyl hexosamine 1-phosphate transferase (PNPT) superfamily <ref name="three">PMID:23990562</ref>. MRAY is a promising candidate for the development of new antibiotics. In fact, it is the target of five classes of natural nucleoside inhibitors with potent antibacterial activity <ref name="two"/> <ref name="four">PMID:29438582</ref>. | ||
The structure presented in this page correspond to the MraY protein | The structure presented in this page correspond to the MraY protein from ''Aquifex aeolicus'' (strain VF5), expressed in ''Escherichia coli'', in complex with carbacaprazamycin. | ||
carbacaprazamycin ( je vais ajouter en peu d'info sur carbacaprazamycin...) | |||
<scene name='61/612822/Aricept_docks_on_tcache/1'>Aricept docked onto AChE</scene> | <scene name='61/612822/Aricept_docks_on_tcache/1'>Aricept docked onto AChE</scene> | ||
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== 3D related structures == | == 3D related structures == | ||
*[[4j72]]:Crystal Structure of polyprenyl-phosphate N-acetyl hexosamine 1-phosphate transferase (MraY) | |||
*[[6oyz]]:Crystal structure of MraY bound to capuramycin | |||
*[[5ckr]]:Crystal Structure of MraY in complex with Muraymycin D2 | |||
*[[6oz6]]:Crystal structure of MraY bound to 3'-hydroxymureidomycin A | |||
*[[5jnq]]:MraY tunicamycin complex | |||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
