Sandbox Reserved 1095: Difference between revisions

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== Functions ==

The AT1 receptors are playing an important role in the regulation of the renin-angiotensin-aldosterone system and therefore in the regulation of the cardiovascular physiology. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions.

AT1 receptors are seven transmembrane-spanning G protein-coupled receptors. They interact with the angiotensin II, their ligand, and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of Angiotensin II, such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex.

When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted: mitogen-activated protein kinase (MAPK) family, extracellular signal regulated kinase (ERK), c-Jun N terminal kinase (JNK), p38MAPK], p70 S6 kinase, AKT/protein kinase B(PKB), various protein kinase C (PKC) isoforms, receptor and non-receptor tyrosine kinases and serine/threonine kinases. This in turn regulates VSMCs contraction via activation of myosin light chain kinase (MLCK) or inhibition of myosin light chain phosphatase (MLCP). The complex functioning of AT1 receptor signalling involve crosstalk with other signalling cascades too.

See also : [https://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_1#Function Angiotensin_II_receptor_type_1 on Wikipedia]

Sandbox Reserved 1095: Difference between revisions

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 <StructureSection load='4zud' size='376' name='AT1R' caption='Human angiotensin receptor'>
 == Functions ==
+The AT1 receptors are playing an important role in the regulation of the renin-angiotensin-aldosterone system and therefore in the regulation of the cardiovascular physiology. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions.
+AT1 receptors are seven transmembrane-spanning G protein-coupled receptors. They interact with the angiotensin II, their ligand, and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of Angiotensin II, such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex.
+When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted: mitogen-activated protein kinase (MAPK) family, extracellular signal regulated kinase (ERK), c-Jun N terminal kinase (JNK), p38MAPK], p70 S6 kinase, AKT/protein kinase B(PKB), various protein kinase C (PKC) isoforms, receptor and non-receptor tyrosine kinases and serine/threonine kinases. This in turn regulates VSMCs contraction via activation of myosin light chain kinase (MLCK) or inhibition of myosin light chain phosphatase (MLCP). The complex functioning of AT1 receptor signalling involve crosstalk with other signalling cascades too.
 See also : [https://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_1#Function Angiotensin_II_receptor_type_1 on Wikipedia]