Sandbox Reserved 1091: Difference between revisions

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== Impact on human body ==

The most common form of disease is one where ''A.sobria'' pathogen adheres to the surface of the intestine causing painful diarrhea, also known as [http://en.wikipedia.org/wiki/Gastroenteritis gastroenteritis]. The enterotoxin activity of the Hemolysin virulence ~~factor~~ of ''A.sobria'' contributes to those symptoms. However, the mortality due to intestinal disease type of infection is low compared to the non-intestinal diseases caused by the ''A.sobria'' infection.

The most common form of disease is one where ''A.sobria'' pathogen adheres to the surface of the intestine causing painful diarrhea, also known as [http://en.wikipedia.org/wiki/Gastroenteritis gastroenteritis]. The enterotoxin activity of the [http://en.wikipedia.org/wiki/Hemolysin hemolysin] [http://en.wikipedia.org/wiki/Virulence_factor virulence factors] of ''A.sobria'' contributes to those symptoms. However, the mortality due to intestinal disease type of infection is low compared to the non-intestinal diseases caused by the ''A.sobria'' infection.

Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence ~~factors~~ than promote their pathogenicity.

Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence factor than promote their pathogenicity.

The nonintestinal form of the disease reports symptoms such as septicemia, lesions of skin and soft tissues as well as meningitis, often ending fatally.

The nonintestinal form of the disease reports symptoms such as [http://en.wikipedia.org/wiki/Sepsis septicemia], lesions of skin and soft tissues as well as [http://en.wikipedia.org/wiki/Meningitis meningitis], often ending fatally. That leads to a crucial reduction in tissue perfusion followed by fatal organ disfunction.

~~leading~~ to a crucial reduction in tissue perfusion followed by fatal organ disfunction.

The ASP induced proteolysis digestion of proteins like kininogen, prothrombin, fibrinogen or prekallikrein at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The kinin system activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation.

The ASP induced proteolysis digestion of proteins like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation.

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Sandbox Reserved 1091: Difference between revisions

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@@ Line 67: / Line 67: @@
 == Impact on human body ==
-The most common form of disease is one where ''A.sobria'' pathogen adheres to the surface of the intestine causing painful diarrhea, also known as [http://en.wikipedia.org/wiki/Gastroenteritis gastroenteritis]. The enterotoxin activity of the Hemolysin virulence factor of ''A.sobria'' contributes to those symptoms. However, the mortality due to intestinal disease type of infection is low compared to the non-intestinal diseases caused by the ''A.sobria'' infection.
+The most common form of disease is one where ''A.sobria'' pathogen adheres to the surface of the intestine causing painful diarrhea, also known as [http://en.wikipedia.org/wiki/Gastroenteritis gastroenteritis]. The enterotoxin activity of the [http://en.wikipedia.org/wiki/Hemolysin hemolysin] [http://en.wikipedia.org/wiki/Virulence_factor virulence factors] of ''A.sobria'' contributes to those symptoms. However, the mortality due to intestinal disease type of infection is low compared to the non-intestinal diseases caused by the ''A.sobria'' infection.
-Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence factors than promote their pathogenicity.
+Once invaded the intestine epithelial cells, Aeromonas can reach any organ via the blood. Multiple virulence factor than promote their pathogenicity.
-The nonintestinal form of the disease reports symptoms such as septicemia, lesions of skin and soft tissues as well as meningitis, often ending fatally.
+The nonintestinal form of the disease reports symptoms such as [http://en.wikipedia.org/wiki/Sepsis septicemia], lesions of skin and soft tissues as well as [http://en.wikipedia.org/wiki/Meningitis meningitis], often ending fatally. That leads to a crucial reduction in tissue perfusion followed by fatal organ disfunction.
-leading to a crucial reduction in tissue perfusion followed by fatal organ disfunction.
-The ASP induced proteolysis digestion of proteins like kininogen, prothrombin, fibrinogen or prekallikrein at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The kinin system activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation.
+The ASP induced proteolysis digestion of proteins like [http://en.wikipedia.org/wiki/Kininogen kininogen], [http://en.wikipedia.org/wiki/Thrombin prothrombin], [http://en.wikipedia.org/wiki/Fibrinogen fibrinogen] or [http://en.wikipedia.org/wiki/Prekallikrein prekallikrein] at restricted sites generates fragments, expressing their own activity and therefore inducing specific physiological reactions. The [http://en.wikipedia.org/wiki/Kinin–kallikrein_system kinin system] activation, for example, reduces the blood pressure while the prothrombin system promotes plasma coagulation.
 ...