Sandbox Reserved 1091: Difference between revisions
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This experimental finding suggests that epithelial trypsin-like proteases mediate the reaction causing enhanced vascular permeability. It is likely that ASP stimulates the secretion and maturation of epithelial trypsin proteases, thus enhancing vascular permeability. ASP could stimulate the [http://en.wikipedia.org/wiki/Bradykinin bradykinin]-releasing pathway, thus stimulating mast cells to release histamine and further enhance the vascular permeability. | This experimental finding suggests that epithelial trypsin-like proteases mediate the reaction causing enhanced vascular permeability. It is likely that ASP stimulates the secretion and maturation of epithelial trypsin proteases, thus enhancing vascular permeability. ASP could stimulate the [http://en.wikipedia.org/wiki/Bradykinin bradykinin]-releasing pathway, thus stimulating mast cells to release histamine and further enhance the vascular permeability. | ||
Antihistaminic agents (diphenhydramine and pyrilamine) were shown to efficiently inhibit vascular permeability enhancing the activity of the ASP. It is very likely that the vascular permeability enhancement is related to the release of histamine from mast cells. | Antihistaminic agents ([http://en.wikipedia.org/wiki/Diphenhydramine diphenhydramine] and [http://en.wikipedia.org/wiki/Mepyramine pyrilamine]) were shown to efficiently inhibit vascular permeability enhancing the activity of the ASP. It is very likely that the vascular permeability enhancement is related to the release of [http://en.wikipedia.org/wiki/Histamine histamine] from [http://en.wikipedia.org/wiki/Mast_cell mast cells]. | ||
Through histopathological examinations it was shown that mast cells appeared around the injection site, confirming the role of | Through histopathological examinations it was shown that mast cells appeared around the injection site, confirming the role of histamine as a key factor. | ||
