Sandbox Reserved 1102: Difference between revisions

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This is an essential step for viral RNA replication. It then provides conditions for the polymerization of RNA by an RNA-dependent RNA polymerase and the methylation of RNA by methyltransferase, which is crucial for Zika replication. In addition, it has been reported that the ATPase activity could alter viral replicative capacity and efficiency and consequently change the host innate immune response.

ATP hydrolysis is the most basic event to the function of this helicase; however, the other dynamic mechanisms remain largely unknown, impeding the further understanding of the function of Zika helicase. <ref> Mechanism of ATP hydrolysis by the Zika virus helicase, The Faseb journal, 27 sep 2018, X. Yang and H. Yang conceived of and designed the experiments; X. Yang, H. Tian, H. Chi, Z. Mu, and T. Zhang performed the experiments; C. Chen, K. Yang, Q. Zhao, Z. Wang, X. Ji, and H. Yang analyzed the data; and X. Yang, C. Chen, X. Liu, and H. Yang wrote the paper.; https://www.fasebj.org/doi/10.1096/fj.201701140R </ref>

ATP hydrolysis is the most basic event to the function of this helicase; however, the other dynamic mechanisms remain largely unknown, impeding the further understanding of the function of Zika helicase.

<ref> Mechanism of ATP hydrolysis by the Zika virus helicase, The Faseb journal, 27 sep 2018, X. Yang and H. Yang conceived of and designed the experiments; X. Yang, H. Tian, H. Chi, Z. Mu, and T. Zhang performed the experiments; C. Chen, K. Yang, Q. Zhao, Z. Wang, X. Ji, and H. Yang analyzed the data; and X. Yang, C. Chen, X. Liu, and H. Yang wrote the paper.; https://www.fasebj.org/doi/10.1096/fj.201701140R </ref>

== Structural highlights ==

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An increased risk of neurologic complications is associated with Zika virus infection in adults and children, including [https://en.wikipedia.org/wiki/Guillain–Barré_syndrome Guillain-Barré syndrome], [https://en.wikipedia.org/wiki/Peripheral_neuropathy neuropathy ] and [https://en.wikipedia.org/wiki/Myelitis myelitis]. Infection during first trimester of pregnancy can cause [https://en.wikipedia.org/wiki/Microcephaly microcephaly] in newborn children.

Like all viruses, ~~zika~~ virus needs to express itself in ~~his~~ host. The helicase permits the unwinding of the DNA, and finally the virus replication.

Like all viruses, Zika virus needs to express itself in its host. The helicase permits the unwinding of the DNA, and finally the virus replication.

It is the non-structural protein 3 (NS3) of the helicase, that is involved in ATP hydrolysis, RNA unwinding and that provides the conditions for RNA polymerization and methylation of RNA which ZIKV needs for replication.

Sandbox Reserved 1102: Difference between revisions

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@@ Line 15: / Line 15: @@
 This is an essential step for viral RNA replication. It then provides conditions for the polymerization of RNA by an RNA-dependent RNA polymerase and the methylation of RNA by methyltransferase, which is crucial for Zika replication. In addition, it has been reported that the ATPase activity could alter viral replicative capacity and efficiency and consequently change the host innate immune response.
-ATP hydrolysis is the most basic event to the function of this helicase; however, the other dynamic mechanisms remain largely unknown, impeding the further understanding of the function of Zika helicase. <ref> Mechanism of ATP hydrolysis by the Zika virus helicase, The Faseb journal, 27 sep 2018, X. Yang and H. Yang conceived of and designed the experiments; X. Yang, H. Tian, H. Chi, Z. Mu, and T. Zhang performed the experiments; C. Chen, K. Yang, Q. Zhao, Z. Wang, X. Ji, and H. Yang analyzed the data; and X. Yang, C. Chen, X. Liu, and H. Yang wrote the paper.; https://www.fasebj.org/doi/10.1096/fj.201701140R </ref>
+ATP hydrolysis is the most basic event to the function of this helicase; however, the other dynamic mechanisms remain largely unknown, impeding the further understanding of the function of Zika helicase.
+<ref> Mechanism of ATP hydrolysis by the Zika virus helicase, The Faseb journal, 27 sep 2018, X. Yang and H. Yang conceived of and designed the experiments; X. Yang, H. Tian, H. Chi, Z. Mu, and T. Zhang performed the experiments; C. Chen, K. Yang, Q. Zhao, Z. Wang, X. Ji, and H. Yang analyzed the data; and X. Yang, C. Chen, X. Liu, and H. Yang wrote the paper.; https://www.fasebj.org/doi/10.1096/fj.201701140R </ref>
 == Structural highlights ==
@@ Line 49: / Line 50: @@
 An increased risk of neurologic complications is associated with Zika virus infection in adults and children, including [https://en.wikipedia.org/wiki/Guillain–Barré_syndrome Guillain-Barré syndrome], [https://en.wikipedia.org/wiki/Peripheral_neuropathy neuropathy ] and [https://en.wikipedia.org/wiki/Myelitis myelitis]. Infection during first trimester of pregnancy can cause [https://en.wikipedia.org/wiki/Microcephaly microcephaly] in newborn children.
-Like all viruses, zika virus needs to express itself in his host. The helicase permits the unwinding of the DNA, and finally the virus replication.
+Like all viruses, Zika virus needs to express itself in its host. The helicase permits the unwinding of the DNA, and finally the virus replication.
 It is the non-structural protein 3 (NS3) of the helicase, that is involved in ATP hydrolysis, RNA unwinding and that provides the conditions for RNA polymerization and methylation of RNA which ZIKV needs for replication.