Sandbox Reserved 1095: Difference between revisions
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AT1 receptors are seven transmembrane-spanning G protein-coupled receptors. They interact with the angiotensin II, their ligand, and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of [https://pubchem.ncbi.nlm.nih.gov/compound/Angiotensin-II Angiotensin II], such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. <ref name="Zhang2015"> PMID: 12676163 </ref> | AT1 receptors are seven transmembrane-spanning G protein-coupled receptors. They interact with the angiotensin II, their ligand, and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of [https://pubchem.ncbi.nlm.nih.gov/compound/Angiotensin-II Angiotensin II], such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. <ref name="Zhang2015"> PMID: 12676163 </ref> | ||
When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted for instance: [https://fr.wikipedia.org/wiki/MAP_kinases mitogen-activated protein kinase (MAPK) family], [https://fr.wikipedia.org/wiki/Extracellular_signal-regulated_kinases extracellular signal regulated kinase (ERK)], [https://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases c-Jun N terminal kinase (JNK)] | When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted for instance: [https://fr.wikipedia.org/wiki/MAP_kinases mitogen-activated protein kinase (MAPK) family], [https://fr.wikipedia.org/wiki/Extracellular_signal-regulated_kinases extracellular signal regulated kinase (ERK)], or [https://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases c-Jun N terminal kinase (JNK)]. The complex functioning of AT1 receptor signalling involve crosstalk with other signalling cascades too.<ref>PMID: 28527699 </ref> | ||
