Sandbox Reserved 1095: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
== Human Angiotensin Receptor == | == Human Angiotensin Receptor == | ||
'''Angiotensin receptors''' belong to the [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G protein coupled receptor (GPCR) family]. | [https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_II '''Angiotensin receptors'''] of type 1 belong to the [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G protein coupled receptor (GPCR) family]. These seven transmembrane-spanning proteins interact with angiotensin II, their ligand, and play therefore a crucial role in the renin-angiotensin-aldosterone system. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. <ref name="Zhang2015"> PMID: 12676163 </ref> | ||
<StructureSection load='4zud' size='376' name='AT1R' caption='Human angiotensin receptor'> | <StructureSection load='4zud' size='376' name='AT1R' caption='Human angiotensin receptor'> | ||
| Line 7: | Line 7: | ||
The AT1 receptors are playing an important role in the regulation of [https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system the renin-angiotensin-aldosterone system] and therefore in the regulation of the cardiovascular physiology. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions. | The AT1 receptors are playing an important role in the regulation of [https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system the renin-angiotensin-aldosterone system] and therefore in the regulation of the cardiovascular physiology. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions. | ||
AT1 receptors | AT1 receptors interact with angiotensin II and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of [https://pubchem.ncbi.nlm.nih.gov/compound/Angiotensin-II Angiotensin II], such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions. | ||
When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted for instance: [https://fr.wikipedia.org/wiki/MAP_kinases mitogen-activated protein kinase (MAPK) family], [https://fr.wikipedia.org/wiki/Extracellular_signal-regulated_kinases extracellular signal regulated kinase (ERK)], or [https://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases c-Jun N terminal kinase (JNK)]. The complex functioning of AT1 receptor signalling involve crosstalk with other signalling cascades too.<ref>PMID: 28527699 </ref> | When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted for instance: [https://fr.wikipedia.org/wiki/MAP_kinases mitogen-activated protein kinase (MAPK) family], [https://fr.wikipedia.org/wiki/Extracellular_signal-regulated_kinases extracellular signal regulated kinase (ERK)], or [https://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases c-Jun N terminal kinase (JNK)]. The complex functioning of AT1 receptor signalling involve crosstalk with other signalling cascades too.<ref>PMID: 28527699 </ref> | ||
