Sandbox Reserved 1095: Difference between revisions
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When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted for instance: [https://fr.wikipedia.org/wiki/MAP_kinases mitogen-activated protein kinase (MAPK) family], [https://fr.wikipedia.org/wiki/Extracellular_signal-regulated_kinases extracellular signal regulated kinase (ERK)], or [https://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases c-Jun N terminal kinase (JNK)]. The complex functioning of AT1 receptor signalling involve crosstalk with other signalling cascades too.<ref>PMID: 28527699 </ref> | When activated by the binding of angiotensin II, AT1R initiates a vascular remodelling activity. By its coupling with the G proteins Gq and Gi of the Gαq/11 subtype, the intracellular signal transduction has started. During these transduction cascades, a large variety of protein kinases are activated. Among them are counted for instance: [https://fr.wikipedia.org/wiki/MAP_kinases mitogen-activated protein kinase (MAPK) family], [https://fr.wikipedia.org/wiki/Extracellular_signal-regulated_kinases extracellular signal regulated kinase (ERK)], or [https://en.wikipedia.org/wiki/C-Jun_N-terminal_kinases c-Jun N terminal kinase (JNK)]. The complex functioning of AT1 receptor signalling involve crosstalk with other signalling cascades too.<ref>PMID: 28527699 </ref> | ||
== History == | == History == | ||
