Sandbox Reserved 1095: Difference between revisions

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{{Sandbox_ESBS_2019}}

== Human Angiotensin Receptor ==

[https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_II '''Angiotensin receptors'''] of type 1 belong to the [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G protein coupled receptor (GPCR) family]. These transmembrane proteins interact with angiotensin II, their ligand, and play ~~therefore~~ a crucial role in the renin-angiotensin-aldosterone system. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. <ref name="Zhang2015"> PMID: 12676163 </ref> They are therefore important for the cardiovascular physiology.

[https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_II '''Angiotensin receptors'''] of type 1 belong to the [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G protein coupled receptor (GPCR) family]. These transmembrane proteins interact with angiotensin II, their ligand, and play a crucial role in the renin-angiotensin-aldosterone system. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. <ref name="Zhang2015"> PMID: 12676163 </ref> They are therefore important for the cardiovascular physiology.

== Functions ==

The AT1 receptors ~~are playing an important role in~~ the regulation of [https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system the renin-angiotensin-aldosterone system] and therefore in the regulation of the cardiovascular system. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions.

The AT1 receptors participate to the regulation of [https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system the renin-angiotensin-aldosterone system] and therefore to the regulation of the cardiovascular system. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions.

AT1 receptors interact with angiotensin II and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of [https://pubchem.ncbi.nlm.nih.gov/compound/Angiotensin-II Angiotensin II], such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions.

Sandbox Reserved 1095: Difference between revisions

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 {{Sandbox_ESBS_2019}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
 == Human Angiotensin Receptor ==
-[https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_II '''Angiotensin receptors'''] of type 1 belong to the [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G protein coupled receptor (GPCR) family]. These transmembrane proteins interact with angiotensin II, their ligand, and play therefore a crucial role in the renin-angiotensin-aldosterone system. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. <ref name="Zhang2015"> PMID: 12676163 </ref> They are therefore important for the cardiovascular physiology.
+[https://en.wikipedia.org/wiki/Angiotensin#Angiotensin_II '''Angiotensin receptors'''] of type 1 belong to the [https://en.wikipedia.org/wiki/G_protein-coupled_receptor G protein coupled receptor (GPCR) family]. These transmembrane proteins interact with angiotensin II, their ligand, and play a crucial role in the renin-angiotensin-aldosterone system. AT1 receptors are predominantly expressed in cardiovascular tissues including heart, endothelium, kidney, vascular smooth muscle cells as well as lungs, brain and adrenal cortex. <ref name="Zhang2015"> PMID: 12676163 </ref> They are therefore important for the cardiovascular physiology.
 <StructureSection load='4zud' size='376' name='AT1R' caption='Human angiotensin receptor'>
 == Functions ==
-The AT1 receptors are playing an important role in the regulation of [https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system the renin-angiotensin-aldosterone system] and therefore in the regulation of the cardiovascular system. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions.
+The AT1 receptors participate to the regulation of [https://en.wikipedia.org/wiki/Renin%E2%80%93angiotensin_system the renin-angiotensin-aldosterone system] and therefore to the regulation of the cardiovascular system. It occupies a crucial place in the maintaining of blood pressure, electrolyte homeostasis, water balance, hormone secretion and renal functions.
 AT1 receptors interact with angiotensin II and are therefore responsible for the triggering of intracellular signal transduction cascades mediating most functions of [https://pubchem.ncbi.nlm.nih.gov/compound/Angiotensin-II Angiotensin II], such as vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal functions.