Sandbox Reserved 1100: Difference between revisions
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== Diseases == | == Diseases == | ||
[http://en.wikipedia.org/wiki/Type_2_diabetes Type II diabete] is caracterized by a chronic hyperglycemia and obese or overweight people most of the time. | [http://en.wikipedia.org/wiki/Type_2_diabetes Type II diabete] is caracterized by a chronic hyperglycemia and obese or overweight people most of the time. In case of type 2 diabete, adiponectin level in plasma signficantly reduced signficantly and the expression adiponectin receptors AdipoR1 (and AdipoR2) decreases in [http://en.wikipedia.org/wiki/Skeletal_muscle skeletal muscle] and [http://en.wikipedia.org/wiki/Adipose_tissue adipose tissues] especially.<ref name="doc3"/> <ref name="doc7"/> | ||
In case of type 2 diabete, adiponectin level in plasma signficantly reduced signficantly and the expression adiponectin receptors AdipoR1 (and AdipoR2) decreases in [http://en.wikipedia.org/wiki/Skeletal_muscle skeletal muscle] and [http://en.wikipedia.org/wiki/Adipose_tissue adipose tissues] especially.<ref name="doc3"/> <ref name="doc7"/> | |||
An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism means that the organism will require more insulin to obtain the biological effects of a normal organism.<ref name="doc8"/> | An [http://en.wikipedia.org/wiki/Insulin_resistance insulin resistant] organism means that the organism will require more insulin to obtain the biological effects of a normal organism.<ref name="doc8"/>From [http://en.wikipedia.org/wiki/Hyperglycemia hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] is probably led insulin resistance.<ref name="doc3"/> The adiponectin levels and the expression of AdipoR1 (and AdipoR2) drop, thereby reduce adiponectin sensitivity and lead to insulin resistance. <ref name="doc8"/> | ||
From [http://en.wikipedia.org/wiki/Hyperglycemia hyperglycemia] and [http://en.wikipedia.org/wiki/Hyperinsulinemia hyperinsulinemia] is probably led insulin resistance.<ref name="doc3"/> The adiponectin levels and the expression | |||
Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increase hyperinsulinemia and start a vicious cycle. <ref name="doc7"/> <ref name="doc3"/> | Then, insulin resistance provoque a drop of adiponectin secretion and circulation level, increase hyperinsulinemia and start a vicious cycle. <ref name="doc7"/> <ref name="doc3"/> | ||
Insulin resistance can be caused by any defects in the insulin signaling cascade included problems with AdipoR1.<ref name="doc8"/> | Insulin resistance can be caused by any defects in the insulin signaling cascade included problems with AdipoR1.<ref name="doc8"/> | ||
