Sandbox Reserved 1093: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 27: | Line 27: | ||
== Function == | == Function == | ||
LRRTM2 protein play a key role in the regulation of the synaptic fonctions and development by interracting with various proteins both inside and outside the neuron cell. | LRRTM2 protein play a key role in the regulation of the synaptic fonctions and development by interracting with various proteins both inside and outside the neuron cell. | ||
'''Interaction with extracellular proteins''' | '''Interaction with extracellular proteins''' | ||
| Line 38: | Line 41: | ||
It has also been noted that the repression of LRRTM2 induced a decrease in the density of PSD-95. Thus, LRRTM2 recruits PSD-95 at postsynaptic density and then binds to PSD-95 via the ECFV cytoplasmic motif. The interaction of PSD-95 with glutamate receptors, located at the postsynaptic membrane, as well as with other synaptic synaptic proteins. | It has also been noted that the repression of LRRTM2 induced a decrease in the density of PSD-95. Thus, LRRTM2 recruits PSD-95 at postsynaptic density and then binds to PSD-95 via the ECFV cytoplasmic motif. The interaction of PSD-95 with glutamate receptors, located at the postsynaptic membrane, as well as with other synaptic synaptic proteins. | ||
By the interaction with important postsynaptic components, LRRTM2 turns out to be crucial in the regulation of the postsynaptic fonctions and plasticity. | By the interaction with important postsynaptic components, LRRTM2 turns out to be crucial in the regulation of the postsynaptic fonctions and plasticity. | ||
[[Image:LRRTM2functions.png|1100px|left]] | [[Image:LRRTM2functions.png|1100px|left]] | ||
