Sandbox Reserved 1093: Difference between revisions
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'''Ligands''' | '''Ligands''' | ||
Neurexins (Nrxns) [http://proteopedia.org/wiki/index.php/Neurexin]is a family of the presynaptic organizer which interact with several postsynaptic organizers such as LRRTM2. | |||
There are three Neurexin genes in vertebrates, each corresponding to a different promoter type. Neurexins are characterized by their laminin-neurexin-sex hormone (LNS) domains. ︎ <scene name='82/829346/Neurexin_1_alpha/1'>α-neurexins</scene> have six whereas ︎<scene name='82/829346/Beta-neurexin_1/2'>β-neurexins</scene> have a single LNS domain. The α-helical conformation causes severe steric hindrance with the bound LRRTM2, whereas the β-stranded conformation causes no obvious steric hindrance. | |||
The structure of the complex <scene name='82/829346/Complex/1'>Nrxn1β–LRRTM2</scene>[http://proteopedia.org/wiki/index.php/5z8y]is being determined by co-crystallisation. A mutation from His 355 to Ala 355 without affecting the complex structure is necessary to maintain the stability of the crystal. | The structure of the complex <scene name='82/829346/Complex/1'>Nrxn1β–LRRTM2</scene>[http://proteopedia.org/wiki/index.php/5z8y]is being determined by co-crystallisation. A mutation from His 355 to Ala 355 without affecting the complex structure is necessary to maintain the stability of the crystal. | ||
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GluD2 [[http://proteopedia.org/wiki/index.php/5cc2]] | GluD2 [[http://proteopedia.org/wiki/index.php/5cc2]] | ||
== Disease == | == Disease == | ||
