Sandbox Reserved 1093: Difference between revisions
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The structure of the complex <scene name='82/829346/Complex/1'>Nrxn1β–LRRTM2</scene>[http://proteopedia.org/wiki/index.php/5z8y]is being determined by co-crystallisation. A mutation from His 355 to Ala 355 without affecting the complex structure is necessary to maintain the stability of the crystal. | The structure of the complex <scene name='82/829346/Complex/1'>Nrxn1β–LRRTM2</scene>[http://proteopedia.org/wiki/index.php/5z8y]is being determined by co-crystallisation. A mutation from His 355 to Ala 355 without affecting the complex structure is necessary to maintain the stability of the crystal. | ||
PSD-95 [http://proteopedia.org/wiki/index.php/1tq3] is a | PSD-95 [http://proteopedia.org/wiki/index.php/1tq3] is a postsynaptic scaffolding protein playing a role in the regulation of the expression of the genes coding for AMPA receptors. This protein also play a role in the translocation of LRRTM2 after the translation. | ||
'''Other synaptic organisers''' | '''Other synaptic organisers''' | ||
Neuroligins (NLs)[http://proteopedia.org/wiki/index.php/3vkf] | Neuroligins (NLs)[http://proteopedia.org/wiki/index.php/3vkf] | ||
LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4) | LRRTM2 bind to Neurexins 1, 2 and 3 ︎and ︎a variant region at splice site 4 in the LNS. As the variant region lacking a 30 amino acid insert (-S4), LRRTM2 cannot induce presynaptic differentiation in neurons. On the contrary, <scene name='82/829346/Neurologin-neurexin/1'>Neuroligin1</scene> binds to Neurexins 1, 2, and 3, has a higher affinity with Neurexin 1 (-S4) than with Neurexin 1 (+S4) | ||
== Disease == | == Disease == | ||
