Sandbox Reserved 1107: Difference between revisions

<scene name='42/421575/Carbacaprazamycin/1'>Carbacaprazamycin</scene> is made of uridine, 5-aminoribosyl, diazepanone, and aliphatic tail moieties. The diazepanone ring system makes relatively few interactions with the protein. Carbacapzazamycin contains an uridine binding pocket which is formed by amino acid residues in Loop C ( <scene name='42/421575/Binding_site/1'>G194, L195, and D196</scene>). This pocket is capped off by a π–π stacking interaction with <scene name='42/421575/Binding_site/1'>F262</scene> in Loop D. <scene name='42/421575/Binding_site/1'>K70</scene> forms an additional hydrogen bond with the uracil moiety. Next to the uridine binding site, there is a second binding pocket lined with amino acid residues<scene name='42/421575/Binding_site/1'> T75, N190, D193, and G264</scene>, called the uridine-adjacent pocket. The 5-aminoribose moiety of carbacaprazamycin forms an extensive hydrogen bond network in the uridine-adjacent pocket <ref name="seven">PMID:31266949</ref>.

== 3D related structures ==